It is well established that CASPR2 autoimmunity is associated with specific HLA alleles, particularly HLA-DRB1*11:01 (Binks et al., 2018; Muñiz-Castrillo et al., 2020), suggesting that an individual’s immunogenetic background may predispose them to produce this autoantibody. The gene discussed is CNTNAP2; the disease is Autoimmunity.