Based on the absence of glucocorticoid drug usage and the presence of clinical symptoms, such as fatigue, anorexia, hyponatremia, etc., the serum concentrations of COR and ACTH should meet one of the following two criteria: (1) COR <5 μg/dL and ACTH <25.0 pmol/L at 8 am on two separate occasions, (2) COR <5 μg/dL and ACTH <25.0 pmol/L at 8 am once, with disappearance of COR/ACTH circadian rhythma. This evidence concerns the gene POMC and Hyponatremia.