APOB and atherosclerosis: The ApoB family includes ApoB100 and ApoB48, with ApoB-100 being the VLDL, LDL, and Lp (a) major structural proteins, and ApoB-48 is the major and irreplaceable apolipoprotein of CM, so every atherogenic lipoprotein contains ApoB particles (8, 9). A prospective cohort study found that the risk of myocardial infarction was strongly associated with the amount of ApoB, independent of lipoprotein type and lipid content, in both primary and secondary prevention cohorts, and that ApoB may be a major driver of atherosclerosis (10).