BGLAP and osteoporosis: Numerous studies have shown that exercise can promote osteogenic differentiation of bone marrow mesenchymal stem cells and osteoblasts, promote bone formation, improve bone metabolism, and thus prevent and control osteoporosis (69).OC is a key osteogenic factor in the process of bone formation, and thus exercise can promote blood circulation and metabolism in the skeleton, which may stimulate osteoblasts to secrete more OC (70).