ADRB2 and obesity due to melanocortin 4 receptor deficiency: This pathway typically operates through β‐adrenergic receptors (β1AR and β2AR), which mediate cAMP signaling and calcium (Ca2+) signaling to control cardiomyocyte function (Sellers et al. 2009; Haodi et al. 2014; Department of Physiology and Biophysics, and Mississippi Center for Obesity Research 2019; Eliezeck et al. 2024).