(16, 25, 36) In addition, concerns regarding potential tumor promotion were not supported by previous studies: GHRH plasmid injection did not increase tumor growth in mice with LL-2 lung adenocarcinoma or in nude mice with carcinomatosis (43, 44), and similarly, no tumor growth promotion was observed in elderly dogs with naturally occurring tumors following GHRH plasmid administration (45). This evidence concerns the gene GHRH and neoplasm.