GHRH and lung adenocarcinoma: (16, 25, 36) In addition, concerns regarding potential tumor promotion were not supported by previous studies: GHRH plasmid injection did not increase tumor growth in mice with LL-2 lung adenocarcinoma or in nude mice with carcinomatosis (43, 44), and similarly, no tumor growth promotion was observed in elderly dogs with naturally occurring tumors following GHRH plasmid administration (45).