The top eight predictors of ADRs were identified by random forest feature importance and association rules as follows: Male, younger age, longer duration on ART, not taking Co‐trimoxazole preventive therapy (CPT), not taking TB (Tuberculosis) preventive therapy (TPT), secondary educational status, TDF‐3TC‐EFV, and low CD4 counts. The gene discussed is CD4; the disease is tuberculosis.