MTFP1 and Adult onset: Professor Erminia Donnarumma’s research team has determined that MTFP1 is critical for cardiac structure and function, and their prior study revealed that constitutive silencing of MTFP1 in mouse cardiomyocytes results in fatal adult-onset dilated cardiomyopathy with expanded mitochondrial and cardiac remodeling during the transition to the heart leads to failure (Marin-Garcia and Akhmedov, 2016).