It has been shown that the process of platelet granule degranulation and exocytosis of biologically active substances from these cells occurs after their activation through receptors, including particularly the protease-activated receptor 4 (PAR4) [3, 7, 84] triggered by factors such as infection, autophagy, as well as interactions with thrombin, ATP, and epinephrine [85, 86]. Here, F2RL3 is linked to infection.