Given these results and the relevance of better understanding the mechanism of action of Riparin A, this study aimed to evaluate the effects of Riparin A on BNDF, VEGF and GluN2B genes expression and cytokine modulation in different brain areas in animals subjected to the chronic unpredictable mild stress (CUMS) model of depression. The gene discussed is GRIN2B; the disease is depressive symptom measurement.