Runt-related transcription factor 2 (RUNX2) is a critical regulator of osteoblast differentiation, it exhibits weak expression in undifferentiated mesenchymal cells, undergoes upregulation during preosteoblastic commitment, and reaches peak expression levels in immature osteoblasts, Located on chromosome 6p21 (1, 2), RUNX2 mutations are associated with cleidocranial dysplasia (CCD) (3, 4), a rare autosomal dominant skeletal disorder with an estimated prevalence of 1 in 1,000,000 (5). This evidence concerns the gene RUNX2 and cleidocranial dysplasia 1.