The selection of KHYG-1 cell line offered two main advantages: first, their close resemblance to primary NK cells and presence of key activating receptors (DNAM-1, NKp30, NKG2D), adhesion receptor (CD11a) and NK cell identifying receptor (CD56) on their surface that help target and adhesion to tumour cells.70, –72 Second, these cells were readily expandable in vitro,29, –31 ensuring a scalable source of membrane for crafting NK cell mimics. The gene discussed is CD226; the disease is neoplasm.