In sepsis, Microglia 1 exhibited strong upregulation of pro-inflammatory genes (e.g., GPNMB, CXCR4, HLA-DRB5) and downregulation of BBB-supportive genes (e.g., SPARCL1, MAP1B), indicating a highly reactive phenotype. The gene discussed is HLA-DRB5; the disease is Sepsis.