Only CD4+CXCL13+GZMB+ TFH-like cells harbor neoantigen-specific TCR clonotypes and could be stimulated by neoantigens to further upregulate GZMB, similar to the increase in GZMB expression upon SEB stimulation in FL and DLBCL. The gene discussed is SETBP1; the disease is diffuse large B-cell lymphoma.