on patients with IBD and mice with DSS-induced colitis demonstrated that macrophages producing the chemokines C-C motif chemokine ligand 7 and C-C motif chemokine ligand 8 recruit more monocytes from the bloodstream into colon tissue; these recruited monocytes serve as a major source of IL-1β and TNF in the inflamed tissue (19). The gene discussed is IL1B; the disease is inflammatory bowel disease.