IL1B and colitis: conducted a study on mice with colitis induced by DSS and on bone marrow-derived macrophage models triggered by LPS; they discovered that salidroside inhibits the activation of the NLRP3 inflammasome by blocking the triggering receptor expressed on myeloid cells 1; this inhibition leads to a reduction in macrophage pyroptosis and decreases the release of the inflammatory factor IL-1β (156).