CD4 and colitis: Consistent with this, in the adoptive T-cell transfer model of colitis, naive CD4+CD45RBhigh T cells from HVEM-deficient donor mice transferred into RAG-deficient recipients, are capable of inducing colitis with only a modest reduction in disease severity compared to wild-type donor T cells, whereas the absence of T−cell−derived LIGHT markedly blunts T−cell expansion and colonic inflammation (17).