BRCA1 and cancer: Mutations in the breast cancer type 1 susceptibility protein (BRCA1) tumor suppressor gene are typically present in hereditary ovarian cancer, leading to the production of large amounts of hydrogen peroxide in cancer cells, which activates NF-κB, induces autophagy, mitophagy, and glycolysis processes in adjacent stromal fibroblasts, and results in Cav-1 loss caused by autophagic digestion.