CAV1 and cancer: Meanwhile, multiple studies have shown that stromal cells lacking Cav-1 are more prone to ROS production, with more obvious inflammatory cell infiltration, including lymphocytes, macrophages, and mast cells, and ROS can lead to mitochondrial dysfunction and DNA damage, drive autophagy and activation of fibroblasts, accelerate glucose metabolism, thereby preventing adjacent epithelial cancer cell death, providing circulating nutrients for cancer cell metabolism, and promoting cancer cell growth (88, 90, 91, 93–97).