The transcriptional upregulation of heat shock 70 kDa protein 8 (HSPA8) in BRAF V600E CRC promotes CMA dependent degradation of Cav-1 and abrogates Cav-1-mediated inhibition of the Wnt/β-catenin pathway, thereby promoting EMT and ultimately leading to the metastasis and progression of BRAF V600E CRC (62). Here, BRAF is linked to colorectal carcinoma.