On the one hand, autophagy activation leads to the degradation of Cav-1 in tumor cells, resulting in downregulation of Cav1 expression; On the other hand, Cav-1 deficiency can activate autophagy by promoting lysosomal function and autophagy lysosome fusion, thereby providing survival advantages for breast cancer cells, facilitating cell survival under stress conditions such as starvation, and thus promoting the development of cancer (83). This evidence concerns the gene CAV1 and cancer.