have revealed that the anticancer drug Sanguisorba officinalis L (SA) plays an anti-tumor metastasis role in breast cancer by inhibiting hypoxia inducible factor-1α (Hif-1 α)/Cav-1 signaling, thereby affecting lysosomal function and inhibiting late stage of autophagy (87). The gene discussed is SETD2; the disease is breast carcinoma.