SQSTM1 and non-small cell lung carcinoma: In A549 (human non-small cell lung cancer, NSCLC) cells, treatment of resveratrol has been reported to increase autophagy, promote autophagy-mediated degradation of p62 and increase the formation of Fas/Cav-1 complex, thereby triggering activation of caspase-8 and cleavage of beclin-1 to initiate apoptosis.