have demonstrated that low expression of Cav-1 and high expression of the autophagy marker ATG4C independently indicate reduced overall survival in epithelial ovarian cancer patients, and a positive correlation between Cav-1 and ATG4C protein expression in cancer cells and stromal cells is confirmed, so Cav-1 and ATG4C may serve as monitoring targets or signaling molecules for tumor progression. This evidence concerns the gene ATG4C and neoplasm.