The up-regulated MGAT5 expression in both HT1 and HT2 groups vs. CTR (Figure 6D) and the higher content of complex-type N-glycans in HT1 (Figure 6C) suggest the importance of branched glycans in the CD25+ pool of CD4+ cells during the early stage of autoimmunization. This evidence concerns the gene CD4 and Autoimmunity.