Notably, CD4+ T cells in T2DM patients secreted significantly higher levels of IL-4 (Figure 3B), predominantly from the memory compartment (Figure 3C), and no change was observed with IL-5, but IL-10 expression was found to be markedly lower in T2DM patients when compared to HCs (Figure 3B). This evidence concerns the gene IL10 and type 2 diabetes mellitus.