Multiple studies have confirmed that the PINK1-Parkin pathway plays a dual role in BPD models: On one hand, in LPS-induced acute lung injury models, the PINK1-Parkin pathway is activated, accompanied by mitochondrial membrane potential loss, upregulation of Bcl-2-associated agonist of cell death protein, and downregulation of Bcl-2, suggesting cross-regulation between mitophagy and apoptosis (Zhang Z. et al., 2020). This evidence concerns the gene PRKN and injury.