While the direct relationship between autosis and BPD remains unclear, the autophagy-mitochondrial axis warrants attention: (1) Autophagy dysregulation (e.g., via Rubicon-Beclin1-Na+/K+-ATPase pathway disruption): may promote cell death by impairing mitochondrial quality control (Li Y. et al., 2020); (2) BPD-associated stressors (e.g., hypoxia/reperfusion) can induce autophagy-dependent death (Nah et al., 2020b), suggesting analogous mechanisms may contribute to mitochondrial dysfunction in BPD. The gene discussed is BECN1; the disease is bronchopulmonary dysplasia.