REST and nervous system disorder: REST was originally discovered as a repressor of neuronal genes in non-neuronal cells (Chen et al., 1998; Jones and Meech, 1999), but several studies have reported that it also serves as an activator, offering neuroprotective effects against multiple neurological disorders (Lu et al., 2014; Pajarillo et al., 2020; Pajarillo et al., 2021).