Endoglin is widely involved in the regulation of inflammation in various immune diseases, including rheumatic diseases, hereditary hemorrhagic telangiectasia-1 (HHT-1), and preeclampsia (Venkatesha et al., 2006; Mangoni and Zinellu, 2024; Hawinkels et al., 2010; Rossi et al., 2016). The gene discussed is ENG; the disease is rheumatic disorder.