ESRCompared to baseline, the fish oil group showed significant increases in docosahexaenoic acid and eicosapentaenoic acid (p < 0.05) and significant decreases in linoleic acid (p < 0.05), CRP (p < 0.05), and sTNF-R p55 (p < 0.05)Interleukin-6 and TNF-a significantly decreased in the fish oil and placebo groups by week 24Patients with RA experienced a decrease in serum levels of sTNF-R p55 and CRP when they were supplemented with n-3 FA and consumed less n-6 FA. The gene discussed is IL6; the disease is rheumatoid arthritis.