INS and rheumatoid arthritis: For 8 weeks, RA patients who took supplements of synbiotics showed improvements in their levels of hs-CRP (p = 0.001), DAS-28 (p < 0.001), VAS (p < 0.001), NO (p = 0.008), insulin (p = 0.01), HOMA-IR (p = 0.03), HOMA-B (p = 0.01), and GSH (p = 0.005)