APOE and Alzheimer disease: 2022). Analyzing the data from a survey given to those > 45 years old to assess behavioral impact demonstrated that, among those factors, the prevalence of hypertension was found to be highest (49.9%), closely followed by reduced physical activity (49.7%) and obesity (35.3%). Interestingly, one study reports that ApoE has a similar correlate to AD as T2DM, more so than other reported risk factors, with hazard ratios of 1.98 and 1.77, respectively (Gottesman et al. 2017).