TTR and poikiloderma with neutropenia: However, the introduction of a non-invasive diagnostic algorithm now enables ∼70% of cases to be diagnosed without the need for histology.3 Alongside these advances in diagnostics, treatments that either stabilize the TTR tetramer or reduce its circulating concentration via inhibition of hepatic synthesis have been shown to slow or halt disease progression in ATTRv amyloid PN (ATTRv-PN) and improve survival in ATTR-CM.