Most reported metastatic GBMs are IDH-wild-type; these often exhibit mesenchymal features or gliosarcomatous differentiation, which are thought to enable greater invasiveness and vascular dissemination. Epithelial-to-mesenchymal transition (EMT) has been identified as a key mechanism promoting glioma cell invasiveness and metastatic potential [9]. This evidence concerns the gene IDH1 and central nervous system cancer.