To investigate whether O-GlcNAcylation of UBAP2L is essential for stress granule (SG) formation, we treated UBAP2L-WT and UBAP2L-S305A overexpression ccRCC cells with sunitinib and performed immunostaining for UBAP2L and G3BP1. This evidence concerns the gene G3BP1 and nonpapillary renal cell carcinoma.