To elucidate TRIM37’s role in UBAP2L regulation, we observed that TRIM37 knockdown increased UBAP2L protein stability, while TRIM37(WT) overexpression, but not the mutants TRIM37(C35/36S), significantly decreased UBAP2L protein stability in ccRCC cells (Fig. 7E and S6H). Here, TRIM37 is linked to nonpapillary renal cell carcinoma.