Furthermore, our observation that FSTL3 overexpression drives EMT in cancer cells autonomously in the KPCA cell line, and that its expression is higher in HGSOC tumors of the mesenchymal histotype in the TCGA, suggest that FSTL3-mediated cancer cell EMT could indirectly contribute to the observed immune checkpoint resistance, through their interactions with T cells [72]. The gene discussed is FSTL3; the disease is cancer.