No APOE4 main effects were observed for AD biomarkers, Aβ42/Aβ40, p-tau and NfL among Mexican Americans, only for total tau (β = -0.1650, 95% CI: (-0.3157, -0.0143), p = 0.0320) and TNF-α (β = -0.1166, 95% CI: (-0.2223, 0.0109), p = 0.0306) (Table 3). Here, APOE is linked to Alzheimer disease.