Interestingly, among the transcripts down-regulated in DUSP8-GFP GdEC#1 and up-regulated in sh-DUSP8-GFP GdEC#1 we found periostin (POSTN) a matricellular protein that has been associated with glioma progression, particularly with glioma angiogenesis [34]. Here, DUSP8 is linked to central nervous system cancer.