At 16 weeks after grafting the volume of the brain invaded by tumor cells was 39.9 ± 1.2 mm3, 15.1 ± 0.6 mm3 and 10.5 ± 0.7 mm3 in mice grafted with GFP, DUSP8 GFP and sh-DUSP8 GFP GSC#1, respectively (mean ± SD, p = 0.001, DUSP8-GFP vs GFP; p = 0.001, sh-DUSP8-GFP vs GFP, Student-t test) (Fig. 6A, lower panel). Here, DUSP8 is linked to neoplasm.