STC1 and glioblastoma: Noteworthy, among the transcripts down-regulated in DUSP8-GFP GSC#1 and up-regulated in sh-DUSP8-GFP GSC#1 we found STC1, a hormone-like protein that exists in the extracellular matrix which contributes to the malignant progression of GBM and is associated with resistance to TMZ therapy [33].