DUSP4 and malignant glioma: Lin and colleagues, showed that dexamethasone treatment inhibited MMP-2 mediated invasiveness of human malignant glioma cells through a DUSP1-dependent mechanism, implicating the tumor suppressor characteristics of DUSP1 [42], as well as, DUSP4 and DUSP26 whose down-regulation correlates with invasive phenotypes of GBM [43, 44].