Analysis of tumor cell proliferation, as assessed by Ki67 labeling index, showed that as compared with GFP expressing tumors, (42.7 ± 6.4, mean ± SD), those grafted with either DUSP8-GFP, sh-DUSP8-GFP GSC#1 cells showed a significantly reduced proliferation in sh-DUSP8-GFP tumors, (21.5 ± 4.1, mean ± SD) and even more reduced in DUSP8-GFP tumors (2.8 ± 1.3, mean ± SD) (Supplementary Fig. S9A-B). This evidence concerns the gene MKI67 and neoplasm.