The volume of the brain invaded by tumor cells at 12 weeks after grafting was 26.9 ± 0.8 mm3, 4.9 ± 1.2 mm3 and 1.8 ± 0.1 mm3 in mice grafted with GFP, DUSP8-GFP and sh-DUSP8-GFP GSC#1, respectively (mean ± SD, p = 0.002, DUSP8-GFP vs GFP; p = 0.0005, sh-DUSP8-GFP vs GFP, Student-t test). The gene discussed is DUSP8; the disease is neoplasm.