SOX4 and osteosarcoma: Similar roles have been observed in other cancers: Wan et al. showed that miR-423-5p reduced glycolysis and metastatic ability in osteosarcoma through Wnt5a/Ror2 signaling [30], while Wen et al. linked the circRNA-miR-423-5p-SOX4 axis to altered glycolysis and tumor growth in papillary thyroid carcinoma [31].