The subsequent functional studies we conducted were showing a consistent modulation of proliferation, migration, invasion, and clonogenic potential: miR-423-5p overexpression induced a milder, less aggressive cancer phenotype, significantly reducing the aforementioned biological effects in all generated HCC cell models compared to their respective controls due, at least in part, to the downregulation of the lncRNA MALAT-1 that, in turn, caused an opposite effect, above all on migration and invasion. Here, MALAT1 is linked to hepatocellular carcinoma.