FADS2 and neoplasm: In tumor cells, FADS2 and SCD1 (a MUFA desaturase) are aberrantly upregulated and confer resistance to ferroptosis.[14, 15] Moreover, additional overexpression of FADS2 contributes to suppressing inflammatory responses in Crohn's disease.[16] Therefore, PUFA desaturase dysfunction may be associated with cellular damage and inflammatory responses, providing important insights into the mechanisms of cell injury in ALI.