FADS1 and acute respiratory distress syndrome: To investigate the endogenous regulatory pathways of FADS1/2, we focused on the antioxidant protein PARK7, based on our previous findings demonstrating its critical role in mitigating endothelial oxidative stress and pyroptosis.[28] Plasma PARK7 concentrations were significantly elevated in patients with SCAP and ARDS compared to the control group (Figure6A).