In tumor cells, FADS2 and SCD1 (a MUFA desaturase) are aberrantly upregulated and confer resistance to ferroptosis.[14, 15] Moreover, additional overexpression of FADS2 contributes to suppressing inflammatory responses in Crohn's disease.[16] Therefore, PUFA desaturase dysfunction may be associated with cellular damage and inflammatory responses, providing important insights into the mechanisms of cell injury in ALI. This evidence concerns the gene FADS2 and Crohn disease.