Previous studies have shown that EPA and DHA supplementation can reduce ferroptosis in neurons of epilepsy conditions by activating NRF2.[43, 44] This effect may be related to maresin 1, an intermediate metabolite of DHA.[45] Our study demonstrates that both direct DHA administration and FADS1/2 overexpression can increase the NRF2/KEAP1 ratio in endothelial cells, indicating NRF2 signaling activation. The gene discussed is NFE2L2; the disease is epilepsy.