ICAM1 and cancer: ICAM‐1 expression does not only serve as a prognostic factor for outcome after treatment in cancer[37] but also plays an important role in the mechanism by which LA might exert their anti‐metastatic properties.[13, 28] In the analysis of all experiments, only high doses of lidocaine were able to significantly decrease ICAM‐1 expression, whereas ropivacaine and lidocaine at low concentrations did not reach statistical significance.