ITGB6 and osteosarcoma: After ITGB6 knockdown, the gene TGM2 was significantly downregulated in all three cell types, In a mouse model of osteosarcoma, both ITGB6 and TGM2 were found to be similarly overexpressed in distal metastatic sites compared to primary lesions, implying further correlation and connection between these proteins of interest35.