INS and type 2 diabetes mellitus: Hyperinsulinaemia due to IR then drives de-novo lipogenesis and ectopic fat deposition in tissues such as the liver and skeletal muscle, further exacerbating IR.3 The aetiology of T2D is multifactorial, and IR in T2D patients is highly heterogeneous, due to differences in molecular pathways manifesting in differing degrees of insulin sensitivity or resistance in target organs.