CTSS and Sepsis: In our study, pseudo-randomization of patients with all-cause sepsis from the MARS cohort (not solely septic shock) stratified according to CTSs, uncovered a harmful signal in CTS1 (inflammatory) and CTS2 (coagulation/fibrinolysis) patients who were treated with corticosteroids; a reanalysis of the VANISH trial suggested harm inflicted by steroid treatment in CTS2 patients.