We propose that the adoption of this new taxonomy, consisting of CTS1 (IL1R2+ and PADI4+ immature neutrophils; inflammatory and endothelial), CTS2 (platelets and eosinophils; heme metabolism and coagulation) and CTS3 (lymphocytes, nonclassical monocytes and NK cells; interferon signaling, Wnt/β-catenin, DNA repair), will enhance future research involving the field of sepsis molecular subtypes and can be adopted by the scientific community for the purpose of resolving sepsis heterogeneity by categorizing the systemic host response. This evidence concerns the gene COMP and Sepsis.