Consistent with the upregulation of HSF1 and DBC1 in mCRPC (Figs. 1a and 7i), metastasis-associated HSF1–DBC1 direct cotarget genes were also upregulated in mCRPC compared with patients with primary PCa (Fig. 7k and Supplementary Fig. 11). The gene discussed is HSF1; the disease is posterior cortical atrophy.