HSF1 and posterior cortical atrophy: The expression of HSF1 was upregulated in advanced CRPC/mCRPC compared with primary PCa tumors (Fig. 1a), and patients with mCRPC with high HSF1 expression had worse survival than those with low HSF1 expression (Fig. 1b), suggesting that HSF1 expression correlates with mCRPC progression and patient outcome.