PLK1 and cancer: A canonical pathway analysis revealed that the AR/AR-V7-independent HSF1–DBC1 cotarget genes were highly enriched in pathways associated with cancer metastasis, including matrisome-related (NABA gene sets), Fanconi, PLK1 and Wnt signaling pathways, compared with HSF1–DBC1-AR/AR-V7 common targets (Supplementary Fig. 6g).