Overabundance of CENP-A ultimately results in genome instability, which is a hallmark of cancer (Athwal et al. 2015; Montes de Oca et al. 2015; Renaud-Pageot et al. 2022; Shrestha et al. 2021; Sullivan et al. 2011; Tomonaga et al. 2003). Here, CENPA is linked to cancer.