MAOB and Parkinson disease: Herein, we investigated the neuroprotective potential of low-nicotine (< 0.04%) N. tabacum extract [11] through a multi-target approach: (1) Inhibition of monoamine oxidase B (MAO-B), a key enzyme in dopamine catabolism; (2) Scavenging of reactive oxygen species (ROS) to mitigate oxidative stress; (3) Protection against 6-Hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells, a validated PD model.