Additionally, through various activity evaluation models, five compounds with MAO-B inhibitory activity, one compound with neuroprotective activity, and two compounds with ABTS radical scavenging activity were discovered in the N. tabacum These findings suggest that N. tabacum harbours multiple neuroprotective activities, including MAO-B inhibition and antioxidative effects, which may contribute to reducing the risk of Parkinson’s disease and potentially other neurodegenerative disorders. Here, MAOB is linked to Parkinson disease.