DUSP6 and neoplasm: In addition to its presence in epithelial tumor cells, our findings suggest that DUSP6 may play a role in the immune cell compartment, which could explain the variability in the expression observed across different human PDAC samples when analyzed via bulk RNA-seq. Notably, DUSP6 expression may also contribute to the formation of the pre-metastatic niche, further underscoring its multifaceted role in PDAC progression.