Despite the counterintuitive nature of DUSP6 overexpression in metastatic samples, given the prevailing dogma suggesting its negative regulation of the ERK/MAPK pathway, our findings were substantiated by further correlation analysis conducted with 30 PDAC cell lines from the Cancer Cell Line Encyclopedia (CCLE) and the Metastasis Map (MetMap 50034). The gene discussed is MAPK1; the disease is cancer.