WWP2 and hydrops fetalis: For example, the index SNP rs1566452 at 16q22.1 locus (PPLACO =  4.46 × 10–8 for LTL-HF) was associated with expression quantitative trait loci (eQTL) in the artery coronary and artery tibial (PArtery_Coronary = 4.06 × 10–5, PArtery_Tibial = 3.32 × 10–10; Supplementary Data 9–10) for WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) gene encoding one of the E3 ubiquitin ligases, which critically participate in the development and progression of cardiovascular diseases37.