The MiT family tRCC is characterized by chromosomal rearrangements that fuse the transcription factor E3 (TFE3) or EB (TFEB) (on chromosomal loci Xp11.2 and 6p21, respectively) with various partners6–10. This evidence concerns the gene TFEB and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.