Similar condensation patterns were also observed with at least five additional tRCC-related TFE3 fusion proteins, including U2AF2-TFE3, KHSRP-TFE3, MATR3-TFE3, RBM10-TFE3 and SPFQ-TFE3, where the fusion partners themselves also demonstrated intrinsic droplet-forming properties (Supplementary Fig. 4c). Here, MATR3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.