TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: In this study, using the NONO-TFE3 fusion protein as a model, we have identified that the RNA binding capability of the TFE3 fusion partner plays a critical role in supporting condensate formation and pro-oncogenic transcription, a common feature shared by several other TFE3 oncofusions found in tRCC patients.