PSPC1 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: To further evaluate whether co-condensation between PSPC1 and NONO-TFE3 supports oncogenic transcription in tRCC, we performed CUT&Tag experiments using antibodies against various RNA polymerase II (RNAPII) forms, including total RNAPII, and serine 2 (S2) or serine 5 (S5) phosphorylated RNAPII (Fig. 5a, and Supplementary Data 4).