SH2B3 and autoimmune disease: Among them, a missense mutation (R262W) present within the LNK/SH2B3 gene has been reported as a risk variant for several autoimmune diseases, including TID and celiac disease, as well as for cardiovascular disorders such as hypercholesterolemia, myocardial infarction, and hypertension (Todd et al, 2007; Hunt et al, 2008; Smyth et al, 2008; Coenen et al, 2009).