CAGE1 and neuroblastoma: All hCT3 CAR T cells exhibited significantly increased cytolytic activity, with nearly 100% specific lysis against the neuroblastoma cell line IMR5 compared to CT3 CAR T cells (80%) at an effector to target (E:T) ratio of 12.5:1 (p < 0.01) (Figures 1F and S2D).