DNMT1 and gastric cancer: ,18,19,20,21 There is an established link between global and intragenic hypomethylation of the genome, typically measured at LINE-1 elements, which has been associated with poor prognosis in patients with gastric cancers and patients with advanced colorectal adenomas47,48,59 and has been used to monitor the efficacy of DNMT1 inhibitors in clinical trials.60