These memory NK cells were more responsive to stimulation with IFNα, resulting in increased production of IFNγ in HIC.<h4>Interpretation</h4>These results suggest that spontaneous HIV control is associated with an NK cell memory phenotype, shaped by HIV infection, epigenetic modifications, and genetic factors.<h4>Funding</h4>The authors are part of the 2000HIV study, which is supported by ViiV Healthcare. This evidence concerns the gene IFNG and HIV infectious disease.