CD274 and neoplasm: In previous studies, when the TME was classified into four categories based on the level of tumor‐infiltrating T cells and PD‐L1 expression, an inflamed TME—considered as a paradigm of adaptive resistance mediated by the PD‐1/PD‐L1 pathway—was characterized by increased PD‐L1 expression and T cell infiltration [27, 28].