Additionally, inhibiting Notch signaling promoted the cytotoxicity of tumor‐infiltrating CD8+ T cells and enhanced the production of pro‐inflammatory cytokines, including interferon‐gamma, tumor necrosis factor‐alpha, interleukin‐1 beta (IL‐1β), IL‐6, and IL‐8, by CD8+ T cells in patients with colorectal carcinoma. This evidence concerns the gene CD8A and neoplasm.