Δ blood glucose was significantly lower with DPP-4 inhibitors vs. placebo (p < 0.00001) but there were no significant difference between the 2 arms concerning CGM data: time in range, time in hyperglycemia, time in hypoglycemia and mean glucose: p = 0.67, p = 0.28, p = 0.08 and p = 0.61 respectively. This evidence concerns the gene DPP4 and Hyperglycemia.