INS and diabetes mellitus: As for diabetes duration, a significant reduction in insulin units was seen only in patients with <3 years of diabetes: MD = −8.30 [−15.85, −0.75] p = 0.03 (for <1 year of diabetes, MD = −3.45 [−5.70, −1.20], p = 0.003; for 1–3 years post diagnosis vs. MD = −2.77 [−5.83, 0.29], p = 0.08; for > 3 years post diagnosis) (S2 Appendix).