SPEN (aka SHARP and MINT) is a co-repressor involved in various signaling pathways, essential for X chromosome inactivation, and recurrently mutated in DLBCL.20–22 As expected, the depletion of SPEN increased mO-OCAB expression, which is consistent with our screening result and SPEN’s prominent repressor function (Figure 1E). This evidence concerns the gene AQP1 and diffuse large B-cell lymphoma.