SPEN and diffuse large B-cell lymphoma: SPEN (aka SHARP and MINT) is a co-repressor involved in various signaling pathways, essential for X chromosome inactivation, and recurrently mutated in DLBCL.20–22 As expected, the depletion of SPEN increased mO-OCAB expression, which is consistent with our screening result and SPEN’s prominent repressor function (Figure 1E).