IRF8 and autoimmune disease: The output includes bar graphs of RRA scores and STRING network visualizations, offering insights into the physical and functional interactions among identified regulators.34Figure 4B presents the B-LEARN regulator analysis of LYN, an Src-family kinase that regulates B cell signaling, cancer, and autoimmune disease.35,36 Among the top LYN activators, we identified the lysine methyltransferase KMT2C and TFs RUNX1, IKZF1/3, and IRF8 (Figure 4B, right).