CD4 and Autoimmunity: ACC1KO mice did not develop any signs of autoimmunity and, compared with WT mice, demonstrated similar percentages of splenic Tregs (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI182480DS1), with similar distributions of naive and memory-like populations of splenic CD4+ and CD8+ Tcons (Supplemental Figure 1, B and C).